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November 1959

Mutations of the Retinal Pigment Cells in a Case of Pseudoglioma

Author Affiliations

Aligarh, India
From the Gandhi Eye Hospital and the Institute of Ophthalmology, Aligarh University.

AMA Arch Ophthalmol. 1959;62(5):785-789. doi:10.1001/archopht.1959.04220050047008

Introduction  Among the most striking cells in diseases of the retina, especially where pseudogliomata are concerned, are the fatty granular cells, generally believed to be fat phagocytes. Coats (1908) believed they were degenerate leukocytes; Leber (1915) said they were derived from the pigment epithelium; Marshall and Michaelson (1933) believed them to be reticuloendothelial cells, and there have been other less likely suggestions. Each point of view has had its supporters.Despite the fact that pseudogliomata are fairly commonplace in India, there emerges from the case to be reported here several interesting features, although that dealing with the retinal pigment epithelium seems the most important; the present study supports Leber's view as to the origin of the fatty granular cells.

Clinical Description  A boy aged 12 attended with grossly defective vision in both eyes. This history dated back for a year only. The onset had been abrupt. Fundus examination revealed an

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