Various authors have demonstrated that the quantity of soluble lens proteins diminishes in the course of development of a cataract, whereas the quantity of albumin increases, particularly in human specimens (Jess, 1913; Hektoen and Schulhof, 1924; Lavagna, 1926; Hertel, 1933; Jayle, Derrien, and Ourgaud, 1944, and Dische and Zil, 1951).
No exact data are available as yet, however, as to the changes which the various soluble proteins are subject to in the course of opacification of the lens, and there is no certainty yet as to the fraction which is first and most markedly affected during this process.
Investigations by Smelser and von Sallmann (1949), into lenses from mice suffering from hereditary cataract, and those by Lewis and Moses (1950), into alloxan-induced cataract in rabbits, have been made with the aid of free electrophoresis according to Tiselius.
1. Our investigations into the pathogenesis of galactose cataract (1954) have shown that
FRANCOIS J, RABAEY M. Agar Microelectrophoresis at High Tension of Soluble Lens Proteins in Cataract. AMA Arch Ophthalmol. 1959;62(6):991-1095. doi:10.1001/archopht.1959.04220060063011