The use of urea as an osmotic agent for the reduction of intraocular pressure has supplanted sucrose and the other drugs classically used for this purpose. The theoretical advantages of urea have been outlined,1 but no comparative study of urea and sucrose that might adduce clinical proof of these advantages has appeared in the literature. Recently, however, it was possible to obtain a patient, a 70-year-old man, on whom a comparison of the effects of intravenously administered urea and sucrose in the commonly used dosage levels could be measured. The results are reported herein.
Materials and Methods
As in past studies, the following routine was used: Blood was obtained for subsequent analysis of freezing point depression and urea nitrogen. Tonography was performed, and shortly thereafter a 30% solution of lyophilized, ammonia-free urea * dissolved in 10% invert sugar was administered intravenously at a rate of about 3 cc. per minute.
GALIN MA, AIZAWA F, McLEAN JM. A Comparison of Intraocular Pressure Reduction Following Urea and Sucrose Administration. AMA Arch Ophthalmol. 1960;63(2):281-282. doi:10.1001/archopht.1960.00950020283011