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May 1960

P32 Localization of Malignant Melanoma of the Posterior Choroid

Author Affiliations

Bethesda, Md.
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Public Health Service, U.S. Department of Health, Education, and Welfare. Present address: Georgetown Medical Center, Washington 7, D.C. (Dr. O'Rourke).

AMA Arch Ophthalmol. 1960;63(5):801-811. doi:10.1001/archopht.1960.00950020803010

Introduction  The diagnosis of melanomas of the choroid by measurement of their P32 uptake has now been attempted for more than seven years. At the present time, evidence that these tumors do concentrate increased amounts of radiophosphorus has been well advanced and there does not seem to be any doubt that the principle on which the test depends is sound. Similarly, in practice there has been little difficulty encountered in defining normal values that have been useful in detecting malignancies of the iris, ciliary body, and anterior choroid.Unhappily, beyond this point, acceptance of the P32 uptake test has been retarded by the failure to detect malignancy of the posterior choroid with methods used for anterior tumors. Recognizing this problem as a limitation imposed by the beta energy spectrum of P32, several investigators have reported the use of curved Geiger tubes applied to the posterior sclera.1,2,3

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