This paper is intended as a comparative study of consecutive attempted intracapsular cataract extractions in a number of unselected cases without using enzyme as compared to the results obtained from attempted intracapsular cataract extractions in a consecutive unselected number of cases in which the enzyme was used.
In by far the majority of cases the cataract was extracted under local akinesia and anesthesia. Following the retrobulbar injection, pressure was applied to the eye for a varying period of time until the eye was extremely soft.Whenever general anesthesia was employed it was supported by a similar retrobulbar injection of 3 cc. of 2% procaine containing hyaluronidase with pressure to the eye subsequent to the injection.In cases in which the enzyme was employed two brands of enzyme were used: (1) Zonulysin supplied by Maw and Sons of Great Britain, and (2) Alpha-Chymotrypsin supplied by British Drug Houses Ltd.
MURRAY RG, DRANCE SM. The Use of Alpha-Chymotrypsin in Cataract Surgery. AMA Arch Ophthalmol. 1960;63(6):910-917. doi:10.1001/archopht.1960.00950020912003