One of the most common injuries of the eye is corneal abrasion, a loss of epithelium from Bowman's membrane. Although a small abrasion may heal within 12 hours, a large one may incapacitate the patient for several days because of intense pain, photophobia, and lacrimation. Furthermore, if healing is delayed, secondary infection may lead to ulceration, with permanent scarring and visual impairment.
Many chemical and physical agents have been proposed to stimulate wound healing but most have proved to be of little benefit. Of those showing promise, nearly all are biological products or derivatives. Schaeffer (1944) observed an increased rate of corneal epithelization in abraded eyes treated with buffered amino acids. Moorhead (1943) used red cell concentrates for surgical wound dressing, and Newell (1947) used red cell concentrates mixed in ointment base to promote corneal epithelization. Although ointments are soothing to painful, denuded corneas, they delay healing and are suspected
CHRISTENBERRY KW. Treatment of Corneal Abrasion with Topical Whole Blood. AMA Arch Ophthalmol. 1960;63(6):948-952. doi:10.1001/archopht.1960.00950020950009