The use of α-chymotrypsin to facilitate intracapsular cataract extraction has aroused widespread interest in the possibilities for enzymatic zonulolysis. Barraquer's1,2 initial reports have been very encouraging and seem to justify the use of this proteolytic enzyme. The effect of this drug appears to be selective for lysing the zonular fibers of the crystalline lens. A recent editorial,3 however, reported three cases of delayed wound closure following the use of α-chymotrypsin. The wide acceptance of this enzyme suggested a need to clarify this possible disadvantage. It seemed desirable, therefore, to undertake such a study.
Cats ranging from 3.0 to 4.5 kg. in weight were used as the experimental animals. The surgical procedure for the control and experimental groups was identical.The nictitating membrane of the eye to be operated was grasped with a toothed forceps and a traction suture placed through it. The maneuver permitted more adequate exposure
FINK AI, BERNSTEIN HN, BINKHORST D. Effect of Alpha-Chymotrypsin on Corneal Wound Healing. AMA Arch Ophthalmol. 1960;64(1):104-107. doi:10.1001/archopht.1960.01840010106009