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November 1960

Experimental Carrageenin Granuloma of the CorneaPreliminary Studies

Author Affiliations

Portland, Ore.
From the John E. Weeks Institute for the Advance of Ophthalmology, University of Oregon Medical School.

Arch Ophthalmol. 1960;64(5):712-723. doi:10.1001/archopht.1960.01840010714014

Healing of surgical wounds, especially those of cataract and retinal detachment operations, is an important current topic in ophthalmology. Since collagen formation is a vital phase of wound healing, recent data indicating that carrageenin is a powerful stimulus to production of collagen makes it of interest to study the effect of this compound on ocular tissues.

Carrageenin is a refined water-soluble hydrocolloid extracted from a seaplant, Irish moss (Chondrus crispus). It is a negatively charged polymer composed of two major fractions, of approximately equal proportions, lambda carrageenin (Fig. 1) and kappa carrageenin (Fig. 2). Both components are polydisperse, are composed of sulfated d-galactose units and have molecular weights in the range of 100,000 to 500,000. Lambda carrageenin is composed almost entirely of these units linked through the 1-3 positions and kappa carrageenin contains one unit of anhydro-d-galactose for approximately every 1.2 units of d-galactose. They form a highly viscous solution

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