Ever since the days of Leber1 ophthalmologists have recognized the occurrence of fungal infections of the eye. Until recently, the major emphasis has been on corneal mycoses.2-5 Relatively few cases of mycotic endophthalmitis have been reported (Cogan;6 Fine and Zimmerman;7,8 Harley and Mishler9). In part this might be explained by the low index of suspicion shared, in the past, by clinicians and pathologists and by the difficulty in histopathologic diagnosis when only routine staining techniques were used. During recent years the availability of a number of good differential stains which facilitate the microscopic recognition of fungi in tissue sections, coupled with an increased awareness by most pathologists of fungus infections, has resulted in an increasing number of cases of mycotic endophthalmitis diagnosed by histopathologic means. To date, such infections have almost invariably led to enucleation because clinical diagnosis and therapy are so very difficult.
FINE BS, ZIMMERMAN LE. Therapy of Experimental Intraocular Aspergillus Infection. Arch Ophthalmol. 1960;64(6):849-861. doi:10.1001/archopht.1960.01840010851005