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Article
February 1961

Papilledema with Hamartoma of Hypothalamus

Author Affiliations

USA; USA, Washington, D.C.
Ophthalmology Service, Walter Reed General Hospital, WRAMC (Capt. Dabezies). Dr. Dabezies is now affiliated with Tulane University, New Orleans. Johns Hopkins Hospital, Baltimore, and Consultant to The Surgeon General, Department of Army, Washington 25, D.C. (Dr. Walsh). Neurosurgery Service, Walter Reed General Hospital, WRAMC (Lt. Col. Hayes).

Arch Ophthalmol. 1961;65(2):174-180. doi:10.1001/archopht.1961.01840020176004
Abstract

A patient with unusual bilateral papilledema and exudative retinopathy was found to have a histologically-proven hamartoma which apparently arose from the region of the hypothalamus. He was an adult in otherwise good general health. There was no history of precocious puberty or abnormal body growth during adolescence, which is unusual in patients having this lesion. To our knowledge this is the first case in which ophthalmoscopic and visual field changes have been noted. The presenting symptom was decreased vision.

Hamartomas are lesions that lie in a "twilight zone" between obvious developmental defects and benign tumors. The derivation of the term "hamartoma" comes from the Greek "hamarto" meaning to fail, plus "-oma" meaning tumor. A hamartoma is defined as a nodular or tumor-like mass resulting from faulty embryonal development of the cells and tissues normally found in that area.1,2,3 The tumor is congenital. It is present at birth and has

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