It has been shown that homograft rejection in general and late clouding of corneal grafts in particular are immunologic processes.1,2 Some of the characteristics of the so-called tissue antigens have been defined, but their exact nature is not yet known.3,4ABO antigens in the human cornea corresponding to those of the red blood cells have been demonstrated by us.5 It was also found that the isoantibody titer rose in the serum of several patients receiving corneal grafts incompatible with their blood group.6-8 These 2 findings stimulated the question as to whether the red cell antigens in the donor cornea are capable of causing late clouding of corneal grafts.The following is a report of experimental perforating keratoplasty in rabbits in which the disease of the graft could be produced by blood group incompatibility between the donor and recipient.
Materials and Methods
Selection of Rabbits.
NELKEN E, NELKEN D, MICHAELSON IC, GUREVITCH J. Late Clouding of Experimental Corneal Grafts. Arch Ophthalmol. 1961;65(4):584-590. doi:10.1001/archopht.1961.01840020586025