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June 1961

The Turnover of Bromide in the Rabbit Eye

Author Affiliations

St. Louis
From the Department of Ophthalmology and the Oscar Johnson Institute, Washington University School of Medicine, St. Louis.

Arch Ophthalmol. 1961;65(6):837-839. doi:10.1001/archopht.1961.01840020839018

The recent finding that iodide is transported out of the rabbit eye1,2 raised the question as to the handling of related halides. The present investigation was an attempt to learn whether bromide is accumulated by ciliary body preparations in vitro and whether it is transported out of the living rabbit eye. The turnover of this anion in ocular fluids after its systemic administration was also measured.

Methods  For in vitro studies ciliary body-iris preparations were incubated in Tyrode's solution containing 0.1μc. Br82/ml. Incubations were carried out with gentle shaking in a water bath at 25 and 37 C for periods of 15 to 60 min. At the end of the incubation, the ciliary body-iris preparations were blotted, weighed, and counted in a well-scintillation counter. They were dried and reweighed. Counts per water content of the cilitary body (T) were compared with the incubation fluid (M) and expressed

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