[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
July 1961

Background to Sickling

Arch Ophthalmol. 1961;66(1):3-5. doi:10.1001/archopht.1961.00960010005003

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


Much basic information about sickle-cell disease has been acquired in recent years, but some aspects remain unclarified. It might be useful to review and discuss briefly certain facts and speculations which concern this hereditary blood dyscrasia of Negroes. An article presenting its conjunctival manifestations is presented elsewhere in this issue.

One fundamental defect of the disease has been established—a genetically determined alteration in amino acid composition of the hemoglobin molecule. Under certain conditions of oxygen tension and pH, red cells containing this hemoglobin form a characteristic sickle shape. Hemolysis and thrombosis are known to be prominent factors in the varied clinical pathology of sickle-cell disease. Undoubtedly, sludging of blood flow is another important factor in the pathogenesis of clinical signs. The conjunctival vascular bed with its readily examined vascular stasis may be of assistance in future studies of the pathophysiology of sickle-cell disease—for it seems a reasonable assumption that the

First Page Preview View Large
First page PDF preview
First page PDF preview