Glaucoma in patients with old inactive syphilitic interstitial keratitis is an entity which presents some unique problems in clinical diagnosis and management. While it is true that penicillin therapy for syphilis has markedly decreased the incidence of acute interstitial keratitis from congenital syphilis, nevertheless the late sequelae continue to present problems. Among the most important of these is the development of glaucoma. The onset of this glaucoma may be insidious with a slow destruction of vision, or it may be acute with an inflamed, painful eye. Sugar1 describes this glaucoma as resulting from healed anterior uveitis which has left open angles but probably an obstruction of the trabecular framework by connective tissue. An analysis of the clinical symptomatology in 23 patients and the histological examination of one eye permits an amplification of his description.
The scanty literature on the glaucoma which may follow interstitial keratitis can be quickly
KNOX DL. Glaucoma Following Syphilitic Interstitial Keratitis. Arch Ophthalmol. 1961;66(1):18-25. doi:10.1001/archopht.1961.00960010020006