It has long been known that the eye is often involved in leukemia and allied disorders. In some reported series clinical observations have been corroborated by biopsy, generally of lids or conjunctiva, and less commonly the globe has been examined. By and large, the exact nature, the extent, and the sites of involvement of the eye by the various reticuloendothelial neoplastic processes remain to be defined.
Intraocular leukemic disease has been noted as a discrete tumor mass by Wiener,1 McGavic,2,3 Reese,4 and others; specific consideration has been given to fundus changes associated with leukemia by Borgeson and Wagener,5 Goldstein and Wexler,6 Gibson,7 and Dawson.8 Involvement of the orbit and adnexa has been well documented,2,3,9-11 and conjunctival disease has been recorded in many detailed reports.12,13,14-16
Within the past 2 years we have had the opportunity to examine the globes of 76 patients
ALLEN RA, STRAATSMA BR. Ocular Involvement in Leukemia and Allied Disorders. Arch Ophthalmol. 1961;66(4):490-508. doi:10.1001/archopht.1961.00960010492010