Vitreous loss during cataract extraction remains a serious hazard. Its incidence has declined with development of improved akinesia, anesthesia, and particularly with the employment of digital compression.1 Nevertheless, ophthalmologists would welcome any technique which could further reduce the occurrence of this complication.
The use of urea as an ocular hypotensive agent prior to routine cataract surgery has not previously been reported. For this reason we undertook to assess the effect of intravenous urea prior to cataract extraction on the incidence of vitreous loss. We reasoned that urea would lower intraorbital, intraocular, and intravitreal pressure to a level which would allow cataract extraction to be performed with greater safety.
We are reporting the results of study on 100 unselected private and ward patients operated upon under the supervision of independent observers at 3 different institutions. The professional level of the operating surgeons includes both resident and attending physicians.
FRIEDMAN B, BYRON H, TURTZ A. Urea in Cataract ExtractionPreliminary Report. Arch Ophthalmol. 1962;67(4):421-423. doi:10.1001/archopht.1962.00960020423007