Sialic acids are N-acetyl, N-glycolyl, or N-O-diacetyl derivatives of neuraminic acid, whose basic structural formula is that of pyruvic acid and mannosamine1 (Fig. 1). In the past decade, sialic acids have been described in a variety of tissues and body fluids as well as in bacteria.2-4 In the eye, sialic acids were estimated in the vitreous in various mammals and lower vertebrates5,6 and were qualitatively studied in the aqueous and the cornea of the steer.7,8
In the present study, the distribution of sialic acids in the human eye has been determined. The concentrations of sialic acids have been related to aging of the eye, particularly that of the lens. Retinal and subretinal fluids were evaluated in terms of content of sialic acids.
Materials and Method
Normal human eyes of children (6 in number) and adults (11 in number) obtained at autopsy were provided by the
HADDAD HM. Sialic Acids in Human EyesRelationship to Lens Aging and Retinal Pathology. Arch Ophthalmol. 1962;67(4):459-463. doi:10.1001/archopht.1962.00960020459013