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To the Editor:
—These objections are valid. In fact, a year or so ago the acute experiments were repeated with the inclusion of a group which received methoxsalen and was exposed to darkness. Ocular lesions did not occur in that group. The chronic experiments have not been repeated as they should be. There is, however, some published evidence that methoxsalen does not produce a chronic effect in the skin in the absence of exposure to long ultraviolet lamps. In addition, the location of so many cataracts in the lower half of the lens suggests that they were due to a lamp suspended overhead. Finally, the ear damage which accompanied the ocular lesions resembled the ear damage due to photosensitization.
Cloud TM. METHOXSALEN PHOTOSENSITIZATION. Arch Ophthalmol. 1962;67(5):686. doi:10.1001/archopht.1962.00960020686029