Antistreptolysin titers (ASLO) have been used for the evaluation of the role of the Streptococcus in the pathogenesis of uveitis. Past studies of serum ASLO titers in uveitis by the author and others1-3 have been uniformly negative.
Laffers and Bozsoky4 have recently reported finding elevated ASLO titers in the aqueous of patients with uveitis, as did Remky,5 who found higher aqueous ASLO titers than serum titers in patients with anterior uveitis. He considered this evidence of local antibody formation in the ocular structures.
Fourteen aqueous and 13 serum samples were collected from 9 uveitis patients. The initial samples were taken within 48 hours of the onset of the attack. Aqueous taps were performed with the Amsler needle on an ambulatory basis. No untoward reactions were noted. The specimens were collected in small glass-stoppered centrifuge tubes and frozen immediately. Blood samples were also taken, centrifuged, and frozen.
COLES RS, LEVENE RZ. Aqueous Antistreptolysin-O Titers in Uveitis. Arch Ophthalmol. 1962;68(1):79-80. doi:10.1001/archopht.1962.00960030083016