Osmotically active ocular hypotensive agents enable the ophthalmologist to operate with less risk. Although urea is popular currently for this purpose, it is not free of certain disadvantages.Therefore, mannitol, an osmotic diuretic, was studied clinically to determine if it might be a more acceptable drug for ophthalmic use.
Materials and Methods
The mannitol was supplied as a 20% solution.* The 17 patients included in this study received a total number of 27 separate intravenous infusions of mannitol. They were predominantly uncontrolled glaucoma patients (Table) at Wills Eye Hospital who were refractory to miotics and carbonic anhydrase inhibitors. An intravenous infusion averaging 1.8 gm. (1.2-3.1 gm.) per kilogram of a 20% solution of mannitol was delivered rather rapidly over a period of 30 to 45 minutes. The average volume was usually about 500 cc. The bottles were prewarmed prior to administration to insure that no crystals were present. A
ADAMS RE, KIRSCHNER RJ, LEOPOLD IH. Ocular Hypotensive Effect of Intravenously Administered MannitolA Preliminary Report. Arch Ophthalmol. 1963;69(1):55-58. doi:10.1001/archopht.1963.00960040061012