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February 1963

Treatment of Total Hyphema with Fibrinolysin

Author Affiliations


Arch Ophthalmol. 1963;69(2):147-153. doi:10.1001/archopht.1963.00960040153003

I. Introduction  In a previous paper1 we reported the successful treatment of 2 eyes with traumatic total hyphema and secondary glaucoma by irrigation with fibrinolysin. The present paper reports data on 8 eyes treated by us and on 56 eyes submitted to us by other ophthalmologists. Fibrinolysin (Thrombolysin)* is a proteolytic enzyme prepared commercially by exposing high concentrations of purified profibrinolysin from human plasma to an activator substance, purified streptokinase. Fibrinolysin has a lytic effect on the fibrin clot, which is dissolved and can be irrigated from the anterior chamber. We also are reporting experimental work with fibrinolysin used in rabbit eyes.

II. Experimental Studies 

  1. Purpose.—Experiments were set up to evaluate the effect of various concentrations of fibrinolysin on ocular tissues when used in the rabbit anterior chamber. The effect of fibrinolysin on experimentally produced hyphema in the rabbit eye was also investigated.

  2. Method of Study.—Albino rabbits

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