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Article
February 1963

Treatment of Malignant Glaucoma with Intravenous Mannitol InfusionMedical Reformation of the Anterior Chamber by Means of an Osmotic Agent: A Preliminary Report

Author Affiliations

New York; San Francisco
From the Department of Ophthalmology and the Glaucoma Clinic University of California Medical Center, San Francisco.

Arch Ophthalmol. 1963;69(2):154-158. doi:10.1001/archopht.1963.00960040160004
Abstract

Malignant glaucoma, appropriately so named by von Graefe in 1869,1 is a dire elevation of intraocular pressure occurring hours, days, or weeks after glaucoma surgery in the shallow-chambered eye with an elevated intraocular pressure,2 and characterized by absence or extreme shallowing of the anterior chamber and a refractoriness to the usual methods of glaucoma therapy. It is an uncommon complication in which there is a forward movement of the lens-iris diaphragm, probably related to sudden loss of anterior chamber aqueous during or soon after surgery. The posteroanterior flow of aqueous humor is blocked, the aqueous being trapped behind a relatively large lens or pooling within the vitreous or behind a detached vitreous body.3

Until recently the medical treatment of malignant glaucoma has been useless, even worsening the prognosis by unduly delaying the necessary surgical measures. Posterior sclerotomy and re-formation of the anterior chamber with air or saline

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