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February 1963

Homoimmune Uveitis in the Guinea PigII. Clinical Manifestations

Author Affiliations

San Francisco
Special Fellow, United States Public Health Service (Dr. Aronson).; From the Department of Ophthalmology and the Francis I. Proctor Foundation for Research in Ophthalmology, University of California School of Medicine.

Arch Ophthalmol. 1963;69(2):203-207. doi:10.1001/archopht.1963.00960040209012

In the first part of this study we discussed the theory of experimental autoimmune and homoimmune uveitis. Four experiments, designed to detect the existence of this type of uveitis, were presented. In Experiment I, 18 pigmented and 18 albino guinea pigs were immunized with large amounts of pigmented uveal antigen-adjuvant suspension over a short period; in Experiment II, 30 pigmented and 30 albino guinea pigs were immunized with pigmented uveal antigen in a low-dose, long-term study. In Experiment III, 20 pigmented and 30 albino guinea pigs were immunized intensively over a short period of time with albino uveal antigen in adjuvant, and in Experiment IV, 12 pigmented guinea pigs were immunized over a long period of time with smaller amounts of pigmented uveal tract in adjuvant. It was found that the pigmented antigen and adjuvant produced uveitis in 57% of pigmented animals in Groups I and II, and 78% in

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