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Article
March 1963

Chromosome Studies in Retinoblastoma

Author Affiliations

New York
From the Department of Medicine, Columbia University College of Physicians and Surgeons, Francis Delafield Hospital, and the Institute of Ophthalmology, Presbyterian Hospital.

Arch Ophthalmol. 1963;69(3):311-313. doi:10.1001/archopht.1963.00960040317009
Abstract

Retinoblastoma is a malignant neoplasm of the retina of infants and young children which is most frequently recognized during the first and second years of life and seldom appears after the sixth year.1,2

The appearance of the neoplasm seems to be sporadic, since, in the majority of cases, no other member of the child's family has a past or present history of the disease.3 However, the numerous reports in the literature of families in which a very high proportion of the members are affected3-7 have led to the recognition of a hereditary form of the disease. Apart from a positive family history and a greater incidence of bilateral cases in the hereditary form of the disease,6,7 no other criteria exist by which the 2 types of retinoblastoma can be distinguished from each other.

The victim of apparently sporadic retinoblastoma, if he survives and marries, may become

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