Retinoblastoma is a malignant neoplasm of the retina of infants and young children which is most frequently recognized during the first and second years of life and seldom appears after the sixth year.1,2
The appearance of the neoplasm seems to be sporadic, since, in the majority of cases, no other member of the child's family has a past or present history of the disease.3 However, the numerous reports in the literature of families in which a very high proportion of the members are affected3-7 have led to the recognition of a hereditary form of the disease. Apart from a positive family history and a greater incidence of bilateral cases in the hereditary form of the disease,6,7 no other criteria exist by which the 2 types of retinoblastoma can be distinguished from each other.
The victim of apparently sporadic retinoblastoma, if he survives and marries, may become
WIENER S, REESE AB, HYMAN GA. Chromosome Studies in Retinoblastoma. Arch Ophthalmol. 1963;69(3):311-313. doi:10.1001/archopht.1963.00960040317009