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Article
March 1963

Colistin in a Pyocyaneus Infection of the Orbit

Author Affiliations

Miami, Fla.
Lecturer in Surgery, University of Miami, School of Medicine (Dr. Meleney).; Plastic Surgical Clinic, Bascom Palmer Eye Institute, University of Miami, School of Medicine (Dr. Amdur).

Arch Ophthalmol. 1963;69(3):322-324. doi:10.1001/archopht.1963.00960040328012
Abstract

Because most strains of Pseudomonas aeruginosa (pyocyaneus) fail to respond to the usual antibiotics, therapy of ocular pyocyaneus infections has become a wellrecognized problem.1,2 The following report illustrates the effect of the antibiotic, colistin, in a case of pyocyaneus infection of the orbit.

With the advent of polymyxin, clinicians felt that a large step forward was made in the therapy of Pseudomonas infections.3 Indeed, topical and subconjunctival polymyxin has been used successfully in curing Pseudomonas corneal ulcers.4-6 When administered systemically, however, polymyxin has toxic effects which seriously limit its usefulness.7

In 1946 Koyama, in Japan, discovered a new antibiotic, colistin,8 similar to polymyxin in antibacterial spectrum but without systemic toxicity in patients when used in clinically effective dosage. Colistin sulfate is not absorbed from the alimentary tract, but acts locally on several different species of the intestinal bacteria. For systemic use, colistin must be given

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