When thioridazine * (2-methylmercapto10-[2-( N-methy1-2-piperidy1 ) ethyl ]-phenothiazine hydrochloride) came to our attention, several members of our staff became impressed with the therapeutic value and minimal side-effects of this phrenotropic agent. Within a short period, over one hundred mentally retarded patients were receiving varying daily dosages of thioridazine for emotional disturbances, behavior and related problems. Since the bibliography on thioridazine is extensive, just a few pertinent references will be given. Kinross-Wright,1 Sandison,2 Jones et al.,3 Hollister and MacDonald,4 Cohen and Pillsbury,5 Oettinger and Simonds,6 Zarling and Hogan,7 Kuberski,8 and Barsa and Saunders9 reported that thioridazine is an effective phenothiazine and, importantly, it produces a lower incidence of side-effects.
Weekley et al.10 reported visual difficulties in 4 out of 29 patients treated with rather large dosages of thioridazine; 2 showed a severe loss of central visual acuity, and all 4 later exhibited
APPELBAUM A. An Ophthalmoscopic Study of Patients Under Treatment with Thioridazine. Arch Ophthalmol. 1963;69(5):578-580. doi:10.1001/archopht.1963.00960040584008