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July 1963

Reaction of Eye Tissues to Heterologous Antiglomerular Antibodies

Author Affiliations

Fulbright grantee, from the Department of Ophthalmology, Keio University, Tokyo, Japan (Dr. Nozaki).; From the Research Department of the Wills Eye Hospital.

Arch Ophthalmol. 1963;70(1):86-95. doi:10.1001/archopht.1963.00960050088014


The lack of a suitable experimental model of endogenous uveitis has been an important obstacle towards achieving a better understanding of the disease. Many characteristics of the disease can be demonstrated in immune responses to foreign protein or whole bacteria cells injected into the aqueous and vitreous or even into the cornea of experimental animals. This direct manipulation of the eye is, however, a serious argument against any claim for production of experimental endogenous uveitis. In its natural development in humans this type of uveitis seldom involves any direct trauma to the eye. For this reason, any procedure that can lead to uveal inflammation without surgical intervention into any part of the eye, can prove to be of great value for future experimentation.

Past attempts to reproduce endogenous uveitis in animals comparable to the human disease have led to failure or to a partial success that was far from

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