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August 1963

Experimental Corneal Vascularization

Author Affiliations

New York
Department of Ophthalmology, New York University-Bellevue Medical Center.

Arch Ophthalmol. 1963;70(2):242-249. doi:10.1001/archopht.1963.00960050244017

Introduction  Vascularization is a fundamental process that occurs normally during tissue growth and abnormally after tissue injury. In the eye, abnormal new vessel formation is an important clinical problem and has received considerable attention. The cornea is an excellent site for the study of new vessel growth by virtue of its normal avascularity and surface location. Neovascularization of the cornea has been reviewed by Ashton1 and Cogan.2During an investigation of experimental glaucoma in the rabbit, produced by an encircling equatorial rubber band, Flocks et al3 noted a circumferential growth of new vessels limited to the peripheral cornea. No direct corneal injury was required. This useful experimental method of producing neovascularization has been used in this study for the further investigation of new vessel growth.

Method  We used adult albino rabbits weighing from 2.5 to 3.0 kg, with normal globes. After a preliminary Schiøtz tonometry on the

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