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August 1963

The Retina in Experimental Diabetic Rats

Author Affiliations

New York; Buenos Aires, Argentina; New York
Professor and Chairman, Institute of Physiology, University of Buenos Aires School of Medicine (Dr. Foglia).; Department of Pathology, New York University School of Medicine (Dr. Lazzarini-Robertson). Part of this work was done during the tenure as Established Investigator, American Heart Association.; From the Department of Ophthalmology, New York University-Bellevue Medical Center.; These studies were supported by a Research Grant-in-Aid NB04229 from the National Institute of Neurological Diseases and Blindness, USPHS, US Department of Health, Education and Welfare. Transportation and part of maintenance costs for these animals was covered by a grant from the American Heart Association (Dr. Lazzarini-Robertson).

Arch Ophthalmol. 1963;70(2):253-255. doi:10.1001/archopht.1963.00960050255019

Diabetic retinopathy in humans is a major ocular problem. The pathogenesis is unknown and treatment is limited. One approach to this problem is the use of experimental diabetic animals. The present investigation is a study of retinal changes in partially pancreatectomized rats maintained for periods up to 27 months without insulin.

Materials and Method  Albino Wistar type rats were partially pancreatectomized (95%) by Dr. Foglia, University of Buenos Aires, at two to three months of age.1 After selection of affected animals by periodic urine glucose determinations, they were sent to Dr. Lazzarini-Robertson, New York University, for general study. For periods up to 27 months, the animals were maintained without insulin on a 15 to 18 gm daily allotment of Wayne Laboratory Blox diet (24% protein and 4% fat). The animals showed glucose blood levels of 390-480 mg% (Somogyi-Nelson) for more than two hours after the glucose-cortisone tolerance test. The

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