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October 1963

The Constrictive Action of Serum and Serum Proteins on the Iris Artery

Author Affiliations

Bethesda, Md
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health, US Public Health Service, Department of Health, Education and Welfare.

Arch Ophthalmol. 1963;70(4):546-553. doi:10.1001/archopht.1963.00960050548020

In recent publications, it has been demonstrated that linear relationships exist between the intrascleral venous pressure of the cat eye and intraocular pressure (IOP)9,11,15 and between the iris artery and intraocular pressures.13 A similar interrelationship was also observed between the femoral and ophthalmic artery pressures in this species; however, no correlation could be demonstrated between the pressures of the ophthalmic artery and the iris artery. It was concluded therefore that the pressure exerted by the systemic circulation was dissociated from the vasculature of the eye at the level of the iris artery. Since previous studies of the cat eye also pointed strongly to a dependence of the IOP on the intraocular venous and iris artery circulation, the concept of a means for the maintenance of IOP based upon a vascular mechanism deserved consideration. A working hypothesis was evolved which, in essence, centered around a controlled dampening of the

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