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November 1963

The EOG in Chloroquine and Other Retinopathies

Author Affiliations

Bethesda, Md
From the Ophthalmology Branch, National Institute of Neurological Diseases and Blindness, National Institutes of Health.

Arch Ophthalmol. 1963;70(5):629-639. doi:10.1001/archopht.1963.00960050631009

The steady potential of the eye and its application to the analysis of ocular movement has been extensively studied and has been called the electro-oculogram (EOG).1 The retinal origin of this potential and the fact that it can be influenced by light have been well demonstrated by earlier investigators.2,3 Recently, Kris4 and Kolder5 independently described the slow and oscillatory time course of this light response in man.

Attempts to use the EOG as a clinical test of retinal function were made by François et al,6-9 the Ten Doesschates,10,11 and Heck and Papst.12 Most recently Arden and collaborators13-17 showed that the sensitivity of such a test can be improved by using the ratio of the maximum light response to the minimum dark level rather than the absolute values of these potential changes.

By using such an approach Arden, Friedmann, and Kolb18 reported

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