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November 1963

Sympathetics in Ocular Sensitization to Circulating Antigen

Author Affiliations

From the Department of Anatomy, Tufts University School of Medicine.

Arch Ophthalmol. 1963;70(5):666-670. doi:10.1001/archopht.1963.00960050668016

Introduction  Intraocular blood vessels are highly impermeable to protein, except when local injury to tissue occurs. At such times a large volume of capillary filtrate, rich in plasma protein, leaks into the surrounding tissue.1 In addition, any foreign protein that happens to be in the general circulation may also leak out and stimulate the production of a localized tissue hypersensitivity. For example, Seegal and Seegal2 produced a mild intraocular inflammation of the rabbit eye by an intra-aqueous injection of dilute glycerine and at the same time introduced egg albumin into the general circulation. Later, an intravenous challenge dose of the same protein caused an immediate-type hypersensitivity reaction in the previously inflamed eye. Similarly, Taylor and Suie3,4 traumatized the rabbit eye with an external mechanical blow and introduced beef albumin into the general circulation. Ten days later, an intravenous challenge dose of the same antigen revealed a state

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