[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.211.180.70. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 1964

Isoflurophate (DFP) in the Handling of Esotropia

Author Affiliations

New York
From Vanderbilt Clinic, Columbia-Presbyterian Medical Center.

Arch Ophthalmol. 1964;71(3):298-302. doi:10.1001/archopht.1964.00970010314003
Abstract

It was just ten years ago that we began to use isoflurophate (DFP; Floropryl) in strabismus cases. We are indebted to S. V. Abraham1,2 for giving us the courage to try this drug after we had been dissatisfied with pilocarpine. After experimenting with various dilutions, we settled on 0.025% as the most practical (that was the weakest dilution that the manufacturer considered stable enough to put on the market in ointment form), and when we found a druggist who would make the dilution properly with an-hydrous peanut oil, we began to get uniform results.

Goodwin Breinin3 has demonstrated in the laboratory how the drug acts—it produces a facilitation of accommodation rather than an actual peripheral stimulation, as was originally thought. This confirmed what we had suspected clinically and explained why it has been rare for the drug to cause blurring of distant vision in low hyperopia or in

First Page Preview View Large
First page PDF preview
First page PDF preview
×