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March 1964

Clinical and Laboratory Evaluation of Idoxuridine (IDU) Therapy in Herpes Simplex Keratitis

Author Affiliations

From the Departments of Ophthalmology, Medicine, and Microbiology, Presbyterian-St. Luke's Hospital.

Arch Ophthalmol. 1964;71(3):325-331. doi:10.1001/archopht.1964.00970010341007

Introduction  In 1960 Tamm1 reported that inhibitors of DNA synthesis could suppress the multiplication of herpes simplex virus in tissue culture. The treatment of herpes keratitis with idoxuridine (5-iodo-2-desoxyuridine, IDU) however, was first suggested by Kaufman.2 He and other authors have reported their generally good results in subsequent communications3-16 in experimentally induced disease in rabbits as well as in the naturally occurring infection in man. Attempts to repeat this work yielded somewhat less encouraging results in our hands and, therefore, a more extensive investigation was initiated. Our studies reported in this paper include: (1) the effect of idoxuridine on herpes keratitis in rabbits and patients, correlated with the presence or absence of demonstrable virus; (2) the influence of the immune status of rabbits on the clinical and virological course of the disease; and (3) the influence of idoxuridine on virus and host cells in a tissue culture

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