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Article
March 1964

Double Nerve Supply of Krause Corpuscles at the Human Corneal Limbus

Author Affiliations

Ann Arbor, Mich
From the Department of Ophthalmology of the University of Michigan Hospital.

Arch Ophthalmol. 1964;71(3):409-411. doi:10.1001/archopht.1964.00970010425020
Abstract

The Krause corpuscles of the conjunctiva and corneal limbus are well known to morphologists and physiologists as sensory receptors for the sensation of cold.1,2 They are formed by relatively thick medullated nerve fibers originating in the ring-shaped paramarginal nerve plexus of Attias.3 These enter the ovoid end-bulbs at their hilum and form a complex entanglement of terminal nerves within. The question whether the Krause end-bulbs have a connective tissue capsule of their own or not and whether the nuclei found accumulated around the entangled nerves are mesodermal or belong to Schwann cells4,5 is not settled. It is known that one nerve fiber in its terminal course may form a number of Krause corpuscles "hanging on them like a cherry on its stalk." Thus, many Krause bodies are seen to have an entrant and an emergent nerve.6

Material and Method  Tissue from the corneal limbus of 11

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