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Dr. Smith's letter was referred to Dr. Armaly, who offers the following reply:
To the Editor:
—I am afraid Dr. Smith is criticizing a hypothesis which I did not propose. Nowhere in my two-page comment of the first paper or the one-page discussion of the second paper did I state as a hypothesis, "that mast cells are the source of the mucopolysaccharides deposited in the trabeculum," let alone propose it with certainty. The evident mood in the entire discussion is an attempt to guess at likely, general, and simplifying explanations that are consistent with an acceptable framework and that could be tested empirically. It was not a pin-pointing of definitive explanations with certainty. The nature of the study and its findings, as well as that of our present knowledge of the parameters involved, do not warrant any other approach. I shall reproduce part of that discussion from page 489 of
Armaly MF. MUCOPOLYSACCHARIDES, MAST CELLS AND STEROID GLAUCOMA-Reply. Arch Ophthalmol. 1964;71(3):447-448. doi:10.1001/archopht.1964.00970010463028