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April 1964

The Effect of 5-Iodo-2-Deoxyuridine (IDU) in Corneal Healing

Author Affiliations

New York
From the Department of Ophthalmology Research, Columbia University, College of Physicians and Surgeons, and the Corneal Unit of the Institute of Ophthalmology, Presbyterian Hospital.; Special Fellow National Institutes of Health (BT-819) (Dr. Polack).

Arch Ophthalmol. 1964;71(4):520-527. doi:10.1001/archopht.1964.00970010536017

Introduction  The antimetabolic activity of 5-iodo-2′-deoxyuridine (IDU) and its effectiveness in the treatment of herpetic keratitis has been reported at length,1-7 the consensus being that this antimetabolite is effective in most cases of superficial herpes of the cornea. When IDU is used in therapeutic doses it does not seem to harm the normal cornea, although the possibility of inhibition of desoxyribonucleic acid (DNA) synthesis by corneal cells,8 and of cellular reproduction9 has been mentioned.Delamore and Prussoff believe that the mechanism of action of IDU varies in different types of cells in vitro.10 For example in mammalian cells IDU can inhibit the formation of thymidine by blocking the formation of orotic and thymidillic acid, precursors of thymidine.11 In the case of herpes virus, IDU can compete with each enzymatic step in the modification and incorporation of thymidine into DNA. This will cause a halt either

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