In a prior publication,1 the authors, utilizing total hyphemas produced in rabbits, demonstrated the effects of streptokinase (Kinalysin) and fibrinolysin (Thrombolysin)* in the resolution of these clots, as compared with untreated and saline irrigated controls. Fibrinolysin is a combination of profibrinolysin (plasminogen) and an activator, streptokinase. Both enzyme preparations promoted resolution of fibrin and corneal edema. Red cell debris, however, was unaffected. Irrigation rather than injection of enzyme was necessary for any substantial benefit.
These results have been confirmed by Scheie et al,2 who found that continuous 30 minute irrigation with fibrinolysin resulted in the clearing of human blood hyphemas in rabbit eyes. Simple injection was ineffectual. Saline irrigation resulted in poor clearing of clot. In addition, Scheie treated traumatic total hyphemas that were six hours to seven days old in human patients. Glaucoma was present. Results were favorable in all including reirrigation in one patient after he
PODOS S, LIEBMAN S, POLLEN A. Treatment of Experimental Total Hyphemas With Intraocular Fibrinolytic AgentsPart II. Arch Ophthalmol. 1964;71(4):537-541. doi:10.1001/archopht.1964.00970010553020