Laboratory investigation of chloroquine retinopathy has been impeded by the difficulty of reproducing symptoms in common laboratory animals comparable to those found in human beings. Some preliminary observations related to this problem are reported herein.
Methods and Materials
In one experiment, 27 hooded and albino rats were subdivided into three groups for high (0.5 mg/ml H2O), moderate (0.167 mg/ml), and no dosages of chloroquine phosphate (Aralen), administered in a continuously available water supply over a threemonth period.Corneal electroretinograms (ERG) were recorded before and after the three-month period. The ERG stimulus was administered by the flash lamp of a Grass model PS2-C photostimulator, at the repetitive rate of 1 per second, at intensity 16, and at a distance of 14 cm from the eye of the darkadapted, anesthetized rat. Flash duration was 10μsec.Central portions of the retinas were examined by light and electron microscopy at the conclusion
Mc CONNELL DG, WACHTEL J, HAVENER WH. Observations on Experimental Chloroquine Retinopathy. Arch Ophthalmol. 1964;71(4):552-553. doi:10.1001/archopht.1964.00970010568022