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To the Editor:
—The article by Dr. T. E. Acers on toxoplasmic retinochoroiditis (Arch Ophthal 71:58-62, 1964) shows considerable thought and imagination in experimental design.Since a significant number of adults have positive Toxoplasma dye tests without specific ocular inflammation, however, the simple finding of a positive dye test cannot establish a definite diagnosis of toxoplasmic uveitis. The evaluation of therapy in the absence of absolute criteria for diagnosis must, therefore, depend on the utilization of large groups of patients. Even assuming that the drugs are highly effective, a study such as this with only ten patients treated with pyrimethamine (Daraprim) and sulfa could not be expected to demonstrate a significant difference between groups. It is impossible, therefore, to draw valid conclusions from such a study and any attempt to do so can be extremely misleading.The only large-scale double-blind studies done in man indicate that pyrimethamine and sulfa are
Kaufman HE. TOXOPLASMIC RETINOCHOROIDITIS. Arch Ophthalmol. 1964;71(4):605. doi:10.1001/archopht.1964.00970010621043