Recent experiments have indicated that high oxygen concentrations have a toxic effect on the adult animal eye. In view of the ever increasing interest in the use of oxygen at high partial pressures, for therapy and for environmental research, the limits of oxygen toxicity in regard to the visual system should be clearly defined.This study was initiated to determine the effects of chronic exposure to high oxygen tensions on the visual mechanisms of the adult animal.
Adult mongrel dogs were exposed to high oxygen environments, ranging from 90% to 100% (680 to 760 mm Hg) in a sealed chamber. Excess moisture was absorbed with Silica Gel, maintaining the humidity between 40% and 90%. Carbon dioxide, absorbed on barium hydroxide, was held below 0.9% and usually averaged below 0.5%. The chamber was located in an air-conditioned room, so that no additional equipment was necessary to hold the temperature
BEEHLER CC, NEWTON NL, CULVER JF, TREDICI TJ. Retinal Detachment in Adult Dogs Resulting From Oxygen Toxicity. Arch Ophthalmol. 1964;71(5):665-670. doi:10.1001/archopht.1964.00970010681013