The possibility that malignant melanoma may be transmitted in a hereditary manner is not often considered. However, Falls1 lists malignant melanoma of the choroid under those eye conditions which may show a dominant hereditary transmission. The following is an example of choroidal malignant melanoma occurring in two successive generations.
Report of Cases
—A 45-year-old white female was admitted to the hospital on May 19, 1953, with a diagnosis of retinal detachment and intraocular tumor, right eye. For three months prior to admission the patient noted a "scum" over right eye. One week prior to admission there was loss of all but light perception in the eye. On examination, the vision in the right eye was limited to light perception. There was a massive retinal detachment with a solid mass behind it. Examination of the patient for metastatic disease revealed no metastases. The family history contained no evidence
BOWEN SF, BRADY H, JONES VL. Malignant Melanoma of Eye Occurring in Two Successive Generations. Arch Ophthalmol. 1964;71(6):805-806. doi:10.1001/archopht.1964.00970010821005