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Article
June 1964

Flicker Fusion Test1. In Neuro-Ophthalmologic Conditions Including Multiple Sclerosis

Author Affiliations

Philadelphia
Present address (Dr. Thorner): Director of Bio-Medical Engineering, Drexel Institute of Technology, 32nd and Chestnut streets, Philadelphia; present address (Mildred Berk): Wills Eye Hospital, 1601 Spring Garden St, Philadelphia.; Department of Neurology, Multiple Sclerosis Unit, University of Pennsylvania.

Arch Ophthalmol. 1964;71(6):807-815. doi:10.1001/archopht.1964.00970010823006
Abstract

It has been over a century since multiple sclerosis was described as a disease entity. Since that time, there has been little advance in knowledge as to the causes of this disease. There is no certainty of diagnosis during the life of the patient. Chiefly, the diagnosis of multiple sclerosis (MS) rests on the presence of frequently recurrent symptoms and the absence of evidence pointing to some other specific cause. Most experienced neurologists would welcome a test to aid them in their diagnosis of MS.

One of the most frequent syndromes found in the histories of MS patients concerns the visual functions. This syndrome usually includes diplopia, diminution of visual acuity, scotoma, and achromatopsia. According to autopsy reports, lesions of the optic pathway occur with a relatively high frequency in MS patients. It is possible that a few cases reporting a syndrome of retrobulbar neuritis may be proved not to

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