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Resurgent interest in the relationship between amebiasis and ocular lesions is evident in the article by King, Praeger, and Hallett, printed elsewhere in this issue. Presenting five cases with distinctive posterior fundus lesions, the authors cite evidence of systemic amebiasis, describe the generally favorable effect of antiamebic therapy, and attribute etiologic significance to Entamoeba histolytica. Though the similarity of the fundus lesions and the response to treatment are impressive, postulating a causal relationship between ocular inflammation and a protozoal disorder involving about 5% of the population has implications of such magnitude that scientific caution is warranted.
Entamoeba histolytica has not been identified in human eyes and, therefore, the diagnosis of amebic chorioretinal disease must be presumptive. Recognizing this, it is recommended that all interested in the relationship between amebiasis and ocular lesions adopt precise criteria for diagnosis and treatment. Certainly, the laboratory diagnosis of amebiasis must be unequivocally established, as
S. BR. Amebiasis and Ocular Lesions. Arch Ophthalmol. 1964;72(1):3-4. doi:10.1001/archopht.1964.00970020005002