Marginal degeneration of the cornea was first described by Trümpy1 in 1881. In 1925, S. R. Gifford2 identified from the ophthalmological literature 52 cases of marginal degeneration and added seven cases of his own. François,3 in 1936, established four stages of the disorder, namely (1) peripheral infiltration (opacity) with vascularization, (2) atrophy of the near-limbus portions, leading to the formation of an external groove, (3) ectasia of portions of the groove, and (4) all-around ectasia. Perforation may then occur as the result of minor trauma.
The case reported in the following is considered remarkable in two respects: The perforation of the cornea in one eye gave rise to a most unusual clinical picture. The other eye responded favorably to a scleral autograft.
Report of a Case
History and Physical Findings.
—A 48-year-old white male was transferred from the Chicago State Mental Hospital to the Illinois Eye and
HINKEN MV. Marginal Degeneration of the CorneaReport of a Case Treated With a Scleral Autograft. Arch Ophthalmol. 1964;72(1):29-31. doi:10.1001/archopht.1964.00970020031007