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To the Editor: I have followed with some interest the correspondence concerning Dr. Thomas Acers' article, "Toxoplasmic Retinochoroiditis: A Double Blind Therapeutic Study" (Arch Ophthal 71:58-62, 1964).
Dr. Acers stressed in his paper and in his letter (Arch Ophthal 71:884-885, 1964) that in the double-blind study done by Dr. Smith, Dr. Schofield, and myself (Brit J Ophthal 40:577, 1956) 50% of those patients with a positive dye-test titer who were treated with a placebo showed progressive improvement and 25% of those with a positive dye test treated with pyrimethamine showed no improvement. I should like to point out that the latter 25% concerns the whole group of uveitis cases treated and includes 98 cases of anterior uveitis which we know are unlikely to be due to toxoplasmosis. The figures for improvement in the relevant group of cases, ie, those of posterior uveitis with a positive dye test, were 88.2% improved
Perkins ES. THERAPY OF TOXOPLASMIC RETINOCHOROIDITIS. Arch Ophthalmol. 1964;72(3):449. doi:10.1001/archopht.1964.00970020449027