Artificial kidney therapy, or hemodialysis, has become of increasing importance in the treatment of patients with uremia. Centers are rapidly being established throughout the country where the life of the patient with end-stage kidney disease can be maintained for a prolonged period of time by dialysis once or twice a week. Thus, it becomes increasingly important to obtain more data regarding the physiological changes occurring during hemodialysis as a result of the rapid shifts in body fluid and solute content.
Patients undergoing hemodialysis often develop such complications as severe headache, nausea, fatigue, and mental confusion. Cardiac arrhythmias, blood pressure changes, and convulsions may occur. In some patients, these changes may be directly related to measurable alterations in fluid and electrolyte balance, while in other patients the cause of these clinical complications is not easily explained. Recently, significant increases in intracranial and intraocular pressure have been demonstrated in uremic dogs undergoing
SITPRIJA V, HOLMES JH, ELLIS PP. Intraocular Pressure Changes During Artificial Kidney Therapy. Arch Ophthalmol. 1964;72(5):626-631. doi:10.1001/archopht.1964.00970020626008