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Dr. Gordon's letter was referred to Dr. Kaufman, who offers the following reply:
To the Editor:
Dr. Gordon may be aware that there were four double-blind studies using idoxuridine. The first study by Patterson indicated that in acute dendritic keratitis 73% of idoxuridine-treated patients were well, as opposed to 7% of placebo-treated. In Burns' study, 65% of idoxuridine-treated patients had a good to excellent response while only 33% of those given placebos were comparably improved. The study by Laibson and Leopold showed 68% good results with idoxuridine, 27% with placebo. Jepson found 92% improved with idoxuridine, 58% with placebo. The study of Luntz and McCallum with 11 patients with heterogeneous disease not evaluated on a double-blind basis is difficult to evaluate. In all four double-blind studies, therefore, idoxuridine was effective, but not always curative. In addition, recent studies by Hanna conclusively prove that the presumptions of Ey based on tissue
Kaufman HE. MANAGEMENT OF HERPES SIMPLEX KERATITIS-Reply. Arch Ophthalmol. 1965;73(1):149-150. doi:10.1001/archopht.1965.00970030150035