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January 1965


Author Affiliations

Chief, Division of Ophthalmology University of Florida College of Medicine Gainesville, Fla 32603

Arch Ophthalmol. 1965;73(1):149-150. doi:10.1001/archopht.1965.00970030150035

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Dr. Gordon's letter was referred to Dr. Kaufman, who offers the following reply:

To the Editor:  Dr. Gordon may be aware that there were four double-blind studies using idoxuridine. The first study by Patterson indicated that in acute dendritic keratitis 73% of idoxuridine-treated patients were well, as opposed to 7% of placebo-treated. In Burns' study, 65% of idoxuridine-treated patients had a good to excellent response while only 33% of those given placebos were comparably improved. The study by Laibson and Leopold showed 68% good results with idoxuridine, 27% with placebo. Jepson found 92% improved with idoxuridine, 58% with placebo. The study of Luntz and McCallum with 11 patients with heterogeneous disease not evaluated on a double-blind basis is difficult to evaluate. In all four double-blind studies, therefore, idoxuridine was effective, but not always curative. In addition, recent studies by Hanna conclusively prove that the presumptions of Ey based on tissue

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