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Dr. Frenkel's letter was referred to Dr. Acers who offers the following reply:
To the Editor:
Dr. Frenkel has most aptly presented the basic problems in establishing clinical specificity to the diagnosis and treatment of toxoplasmic retinochoroiditis.Emphasis on the dual pathogenesis of ocular toxoplasmosis is most appropriate, and essential to our understanding of this disease process. The mechanisms of "tissue hypersensitivity" and "organism proliferation" certainly must be carefully considered, diagnostically and therapeutically.The question of which pathogenic mechanism is definitely involved in the individual patient is, of course, irresolvable from our clinical evaluation. Dr. Frenkel and I both feel that 90% or more of the human cases of ocular toxoplasmosis fall into this category of hypersensitive reactions. The group of patients described in the article with localized active exudative retinitis with localized retinal edema and necrosis, cutaneous hypersensitivity, positive methylene blue dye test titre, and evidence of old (more
Acers TE. TOXOPLASMIC RETINOCHOROIDITIS-Reply. Arch Ophthalmol. 1965;73(2):306-307. doi:10.1001/archopht.1965.00970030306031