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April 1965

Ocular Changes in Multiple Myelomatosis

Author Affiliations

From the Department of Pathology, Institute of Ophthalmology, University of London.

Arch Ophthalmol. 1965;73(4):487-494. doi:10.1001/archopht.1965.00970030489008

Multiple myelomatosis may involve the eye and adnexa in a variety of ways,1,2 which can be classified into two groups: (1) lesions resulting directly from the neoplasm itself, for example, invasion of the orbital bones and orbital cavity, compression of the cranial nerves with loss of vision and with oculomotor palsies, papilledema from raised intracranial pressure, intraocular infiltration,3 etc; (2) lesions resulting from associated blood changes. As is well known, multiple myelomatosis is a disease in which a disturbance of proteins is a characteristic feature4 giving rise to hyperproteinemia with increased viscosity and sludging of the blood, Bence-Jones proteinuria, and paramyloidosis. In the eye protein deposits have been found in the cornea,5 and a characteristic fundus picture may develop with vascular tortuosity and engorgement, exudates, and hemorrhages; actual venous thrombosis has been described and glaucoma ensued.6

In the literature there are few pathological examinations of

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